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selective ccr2 antagonist rs-504393  (AbMole Bioscience)

 
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    AbMole Bioscience selective ccr2 antagonist rs-504393
    Selective Ccr2 Antagonist Rs 504393, supplied by AbMole Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective ccr2 antagonist rs-504393/product/AbMole Bioscience
    Average 90 stars, based on 1 article reviews
    selective ccr2 antagonist rs-504393 - by Bioz Stars, 2026-02
    90/100 stars

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    Normalized CCR2 (A), MCP1 (B), MCP2 (C), MCP3 (D), and MCP4 (E) mRNA expression (mean ± SEM) within the follicle wall at different time points (6, 12, 24, and 36 h) in culture in the absence (control, gray bars) or presence of LH (LH, black bars) assessed by quantitative real-time PCR. 18S rRNA served as the invariant control for normalization. Two-way ANOVA analyses (Time × Treatment) showed significant difference (P < 0.05) among some of the mRNA expression assessed. A significant effect (P < 0.05) by time was observed for the mRNA expression of MCP1 (B: C6 vs. C12, C24, and C36; LH6 vs. LH12 and LH24; LH12 vs. LH36; LH24 vs. LH36) and MCP3 (D: C6 vs. C12; C12 vs. C36). In contrast, the expression of the receptor CCR2 and the chemokines MCP2 and MCP4 did not change (P > 0.05) within the follicle wall, regardless of LH treatment or time (A, C, and E).

    Journal: Biology of Reproduction

    Article Title: Direct role of the C-C motif chemokine receptor 2/monocyte chemoattractant protein 1 system in the feline cumulus oocyte complex †

    doi: 10.1093/biolre/ioy237

    Figure Lengend Snippet: Normalized CCR2 (A), MCP1 (B), MCP2 (C), MCP3 (D), and MCP4 (E) mRNA expression (mean ± SEM) within the follicle wall at different time points (6, 12, 24, and 36 h) in culture in the absence (control, gray bars) or presence of LH (LH, black bars) assessed by quantitative real-time PCR. 18S rRNA served as the invariant control for normalization. Two-way ANOVA analyses (Time × Treatment) showed significant difference (P < 0.05) among some of the mRNA expression assessed. A significant effect (P < 0.05) by time was observed for the mRNA expression of MCP1 (B: C6 vs. C12, C24, and C36; LH6 vs. LH12 and LH24; LH12 vs. LH36; LH24 vs. LH36) and MCP3 (D: C6 vs. C12; C12 vs. C36). In contrast, the expression of the receptor CCR2 and the chemokines MCP2 and MCP4 did not change (P > 0.05) within the follicle wall, regardless of LH treatment or time (A, C, and E).

    Article Snippet: Normalized AREG (a) and HAS2 (b) mRNA expression (mean ± SEM) within the COC after 3 h in culture in the presence of MCP1 (10 or 100 ng/ml) with or without the highly selective CCR2 chemokine receptor antagonist (1 μM, RS 504393, Tocris Biosciences).

    Techniques: Expressing, Control, Real-time Polymerase Chain Reaction

    Normalized CCR2 (A), MCP1 (B), MCP2 (C), and MCP3 (D) mRNA expression (mean ± SEM) within the COC at different time points (6, 12, 24, and 36 h) in culture in the absence (control, gray bars) or presence of LH (LH, black bars) assessed by quantitative real-time PCR. 18S rRNA served as the invariant control for normalization. Significant differences affected by time and treatment of CCR2 mRNA expression were observed within the COC (A: C6 vs. LH6; LH6 vs. LH12 and LH24; LH12 vs. LH36; LH24 vs. LH36). In contrast, MCP2 mRNA expression significantly changed (P < 0.05) in time only in the control group (C: C6 vs. C36; C24 vs. C36). MCP1 and MCP3 mRNA expression within the COC (B and D) did not show any significant difference either in treatment or time (P > 0.05).

    Journal: Biology of Reproduction

    Article Title: Direct role of the C-C motif chemokine receptor 2/monocyte chemoattractant protein 1 system in the feline cumulus oocyte complex †

    doi: 10.1093/biolre/ioy237

    Figure Lengend Snippet: Normalized CCR2 (A), MCP1 (B), MCP2 (C), and MCP3 (D) mRNA expression (mean ± SEM) within the COC at different time points (6, 12, 24, and 36 h) in culture in the absence (control, gray bars) or presence of LH (LH, black bars) assessed by quantitative real-time PCR. 18S rRNA served as the invariant control for normalization. Significant differences affected by time and treatment of CCR2 mRNA expression were observed within the COC (A: C6 vs. LH6; LH6 vs. LH12 and LH24; LH12 vs. LH36; LH24 vs. LH36). In contrast, MCP2 mRNA expression significantly changed (P < 0.05) in time only in the control group (C: C6 vs. C36; C24 vs. C36). MCP1 and MCP3 mRNA expression within the COC (B and D) did not show any significant difference either in treatment or time (P > 0.05).

    Article Snippet: Normalized AREG (a) and HAS2 (b) mRNA expression (mean ± SEM) within the COC after 3 h in culture in the presence of MCP1 (10 or 100 ng/ml) with or without the highly selective CCR2 chemokine receptor antagonist (1 μM, RS 504393, Tocris Biosciences).

    Techniques: Expressing, Control, Real-time Polymerase Chain Reaction

    Representative confocal microscopy images ×20 (A, C) and ×60 (B, D) of feline COCs after inmunofluorescensce [blue = Hoechst, green = F-actin, red = CCR2 (A, B) or MCP1 (C, D)]. No staining was observed in the negative control (inserts). The chemokine receptor CCR2 and its principal ligand (MCP-1) immunostaining was observed in the oocyte and the cumulus cells. Bar represents 50 μm.

    Journal: Biology of Reproduction

    Article Title: Direct role of the C-C motif chemokine receptor 2/monocyte chemoattractant protein 1 system in the feline cumulus oocyte complex †

    doi: 10.1093/biolre/ioy237

    Figure Lengend Snippet: Representative confocal microscopy images ×20 (A, C) and ×60 (B, D) of feline COCs after inmunofluorescensce [blue = Hoechst, green = F-actin, red = CCR2 (A, B) or MCP1 (C, D)]. No staining was observed in the negative control (inserts). The chemokine receptor CCR2 and its principal ligand (MCP-1) immunostaining was observed in the oocyte and the cumulus cells. Bar represents 50 μm.

    Article Snippet: Normalized AREG (a) and HAS2 (b) mRNA expression (mean ± SEM) within the COC after 3 h in culture in the presence of MCP1 (10 or 100 ng/ml) with or without the highly selective CCR2 chemokine receptor antagonist (1 μM, RS 504393, Tocris Biosciences).

    Techniques: Confocal Microscopy, Staining, Negative Control, Immunostaining

    Normalized CCR2 (A) and MCP1 (B) mRNA expression (mean ± SEM) within the COC after 3 h in culture in the absence (control) or presence of MCP1 (10 or 100 ng/ml). Different letters represent significant differences between groups (P < 0.05).

    Journal: Biology of Reproduction

    Article Title: Direct role of the C-C motif chemokine receptor 2/monocyte chemoattractant protein 1 system in the feline cumulus oocyte complex †

    doi: 10.1093/biolre/ioy237

    Figure Lengend Snippet: Normalized CCR2 (A) and MCP1 (B) mRNA expression (mean ± SEM) within the COC after 3 h in culture in the absence (control) or presence of MCP1 (10 or 100 ng/ml). Different letters represent significant differences between groups (P < 0.05).

    Article Snippet: Normalized AREG (a) and HAS2 (b) mRNA expression (mean ± SEM) within the COC after 3 h in culture in the presence of MCP1 (10 or 100 ng/ml) with or without the highly selective CCR2 chemokine receptor antagonist (1 μM, RS 504393, Tocris Biosciences).

    Techniques: Expressing, Control